Parlodel

Parlodel® Leaflet bromocriptine mesilate What is in this leaflet This leaflet answers some common questions about Parlodel. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the final page. More recent information on the medicine may be available. You should ensure that you speak to your pharmacist or doctor to obtain the most up to date information on the medicine. Those updates may contain important information about the medicine and its use of which you should be aware. All medicines have risks and benefits. Your doctor has weighed the risks of you taking Parlodel against the benefits they expect it will provide. If you have any concerns about this medicine, ask your doctor or pharmacist. Keep this leaflet with the medicine. You may need to read it again. What Parlodel is used for Parlodel has several uses. It can be used for the following medical conditions: 1. Prevention/suppression of breast milk production (lactation) in women who cannot/do not breast-feed for medical reasons. If breast milk production has already begun, your doctor can advise you about other methods of stopping lactation. 2. Treatment of people who have high blood levels of a hormone called prolactin. This condition is sometimes caused by a type of tumour called a prolactinoma. 3. Treatment of acromegaly, a disease in which the body produces too much growth hormone. Parlodel treats this disease by reducing the level of growth hormone in the blood. 4. To relieve symptoms, such as shaking of the limbs, stiffness and slowness of movement, in people with Parkinson's disease. Parlodel is often used in combination with other medicines such as levodopa. Parlodel contains the active ingredient, bromocriptine. It belongs to a group of medicines known as the ergot alkaloids, derived from a type of fungus. Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed it for another reason. This medicine is only available with a doctor's prescription. It is not addictive. Parlodel may be used with caution in older people. There is not enough information to recommend this medicine for children. Before you take Parlodel When you must not take it Do not take Parlodel if you have an allergy to: • bromocriptine (the active ingredient) or any of the other ingredients of Parlodel listed at the end of this leaflet • any other medicines containing ergot alkaloids. Some of the symptoms of an allergic reaction may include shortness of breath, wheezing. How to take Parlodel All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on: your age the condition being treated the severity of your condition other medical conditions you have how you react to the first dose Dosage for hyperprolactinemia-associated disorders Generic: Bromocriptine Form: oral tablet Strength: 2.5 mg Brand: Parlodel Form: oral tablet Strength: 2.5 mg Adult dosage (ages 16 years and older) Typical starting dosage: One-half to 1 tablet (1.25–2.5 mg) once per day. Increasing dosage: Your doctor may increase your dosage by 1 tablet every 2 to 7 days until your condition is controlled. Typical daily dosage: 2.5–15 mg once per day (in 2.5 or 5 mg tablets). Child dosage (ages 11–15 years) Prolactin-secreting pituitary tumor is the only condition that bromocriptine has been studied to treat in children younger than 16 years. Clinical trials in adults support the use of bromocriptine in children ages 11–15 years to treat this condition. Typical starting dosage: One-half to 1 tablet (1.25–2.5 mg) once per day. Increasing dosage: Your doctor may increase your child’s dosage as needed. Typical daily dosage: 2.5–10 mg once per day. Child dosage (ages 0–10 years) It hasn’t been confirmed that bromocriptine is safe and effective for people younger than 11 years in the treatment of hyperprolactinemia-associated disorders. Dosage for acromegaly Generic: Bromocriptine Form: oral tablet Strength: 2.5 mg Brand: Parlodel Form: oral tablet Strength: 2.5 mg Adult dosage (ages 16 years and older) Typical starting dosage: One-half to 1 tablet (1.25–2.5 mg) once per day at bedtime for the first three days. Increasing dosage: Your doctor may increase your dosage as needed every 3 to 7 days. Typical daily dosage: 20–30 mg once per day. Maximum daily dosage: 100 mg once per day. Child dosage (ages 0–15 years) It hasn’t been confirmed that bromocriptine is safe and effective for people younger than 16 years in the treatment of acromegaly. Dosage for Parkinson’s disease Generic: Bromocriptine Form: oral tablet Strength: 2.5 mg Brand: Parlodel Form: oral tablet Strength: 2.5 mg Adult dosage (ages 16 years and older) Typical starting dosage: One-half tablet (1.25 mg) twice daily with meals. Increasing dosage: Your doctor may increase your dosage by 1 tablet every 14 to 28 days as needed. Maximum daily dosage: 100 mg once per day. Child dosage (ages 0–15 years) It hasn’t been established that bromocriptine is safe or effective for people younger than 16 years in the treatment of Parkinson’s disease. Dosage for type 2 diabetes Brand: Cycloset Form: oral tablet Strength: 0.8 mg Adult dosage (ages 16 years and older) Typical starting dosage: One 0.8-mg tablet taken once daily, with food, within 2 hours of waking in the morning. Increasing dosage: Your doctor may increase your dosage by 1 tablet once per week until you reach the appropriate dosage for you. Typical maintenance dosage: 1.6–4.8 mg taken once daily, with food, within 2 hours of waking in the morning. Maximum daily dosage: 6 tablets (4.8 mg) taken once daily, with food, within 2 hours of waking in the morning.

Stilbestrol 5mg

Stilbestrol Tab is a strong agonist of the oestrogen receptor. It is also used in the treatment of menopausal and postmenopausal diseases, as well as to prevent miscarriage or early delivery in pregnant women who are at risk. Stilbestrol Tab can be taken with or without food. Stilbestrol treatment is not effective in "drying up" the milk more rapidly in patients who do not want to nurse.

Infant Formulas Sold in Nigeria Found Toxic

Infant formulas sold in Nigeria are useful alternatives to breast milk in many circumstances but may pose health risks to infants and children due to contamination by potentially toxic metals, a study has said.

In the study published in the 2020 Sultan Qaboos University Medical Journal, scientists tested different brands of both locally manufactured and imported infant formulas and found their content of arsenic was higher than the provisional tolerable level, suggesting a cause for public health concern.

Arsenic can cause cancer in many organs, including the skin, lungs, bladder, kidney and liver; it is also capable of influencing the neurological, respiratory and cardiovascular systems.

The study also compared the estimated daily intake of aluminium, arsenic and mercury with the provisional tolerable daily intake acceptable by the Joint Food and Agricultural Organisation/World Health Organisation Expert Committee on Food Additives in 26 infant formulas purchased in March, 2017 from stores in Port Harcourt.

This sample represented approximately 75 per cent of infant formulas available on the Nigerian market. It consists of infant formulas and follow-on formula samples which were soy-based, milk and rice-based, rice, wheat and mixed cereal gruel (all sold as powder), vegetable meals, and fruit-based desserts.

Aluminium and mercury levels were within permissible limits, but arsenic concentrations in the infant formulas exceeded established safe limits.

The concentrations of aluminium and mercury were highest in milk-based infant formulas compared to other types, whereas arsenic was lowest in milk-based infant formulas compared to other analysed types.

The levels of arsenic were higher in cereal-based formulas compared to milk-based formulas, but the difference was not significant.

The intake levels of aluminium, arsenic and mercury in infant formulas were found to be 8.02–14.2 per cent, 437.1–771 per cent and 23.7–41.8 per cent of the provisional tolerable daily intake of the JECFA threshold values, respectively.

According to them, food regulatory agencies in developing nations should maintain regular and periodic checks of foods to ensure permissible limits of contaminants.

They declared that further studies with larger sample sizes including metal speciation analyses will shed more light on the public health impact of infant formula consumption in Nigeria.

Currently, there is no guideline for arsenic content in baby food, including infant formulas, but the food industry has been advised to adhere to a 0.2 mg/kg arsenic level to ensure the safety of infants and young children.

Infant formulas derived from rice have been shown to contain arsenic, which potentially has health risks for infants due to long-term exposure starting at a young age.

Source: https://tribuneonlineng.com/infant-formulas-on-sale-in-nigeria-high-in-arsenic-toxic-substance/